Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWFD5C)

• Drug Name: 3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione Drug Info
• Synonyms: 3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione; CHEMBL566906; BDBM50303356

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 44626811
  TTD Drug ID: DMWFD5C

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

References

• [1] 4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase. J Med Chem. 2010 Jan 14;53(1):241-53.