Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWI9XS)

Drug Name
2,3-Dihydro-1H-isoindole Drug Info
Synonyms
Isoindoline; 496-12-8; 2,3-dihydro-1H-isoindole; 1H-Isoindole, 2,3-dihydro-; Isoindoline, 97%; CHEMBL118475; GWVMLCQWXVFZCN-UHFFFAOYSA-N; iso-indoline; 2-Azaindan; 1,3-dihydroisoindole; 1,2-dihydroisoindole; PubChem16248; ACMC-1AM9E; AC1Q1IE0; AC1L9MF9; 1,3-dihydro-2H-isoindole; SCHEMBL10612; KSC222C5F; SCHEMBL2764305; CTK1C2152; MolPort-000-165-448; KS-000013BD; BCP01139; ACN-S003606; ZINC4111883; ACN-S001460; ANW-30800; STK077165; BDBM50052887; AN-716; BBL000565; AKOS000283835; TRA0077123; RTC-060566; CM10320; MB01342
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
422478
CAS Number
CAS 496-12-8
TTD Drug ID
DMWI9XS

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-meth... J Med Chem. 1996 Aug 30;39(18):3539-46.