Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWIJTN)

Drug Name

Voclosporin Drug Info

Synonyms

Luveniq; ISAtx-247; ISA-247; UNII-2PN063X6B1; ISATX247; 515814-01-4; ISA247; 2PN063X6B1; ISA 247; trans-ISA-247; LX211; Voclosporin (USAN/INN); Voclosporin [USAN:INN]; Voclera; 3odi; LX-211; LX-214; ISA247, Luveniq; AC1OCFHS; R-1524; SCHEMBL12632344; CHEBI:135957; (E)-ISA-247; DB11693; 515814-00-3; HY-106638; CS-0026210; D09033; Cyclosporin A, 6-((2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid)-; 368455-04-3; Luveniq; Voclosporin [USAN]; R 1524; Trans-ISA 247; Trans-ISA-247; TrkA-IgG

Indication

Disease Entry	ICD 11	Status	REF
Lupus nephritis	4A40.0Y	Approved	[1]
Psoriasis vulgaris	EA90	Phase 3	[2]
Kidney disease	GC2Z	Phase 2	[2]

Cross-matching ID

PubChem CID: 6918486
ChEBI ID: CHEBI:135957
CAS Number: CAS 515814-00-3
TTD Drug ID: DMWIJTN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcineurin (PPP3CA)	TTA4LDE	PP2BA_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Calcineurin (PPP3CA)	DTT	PPP3CA	6.282	7.43	6.685	6.815

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Lupus nephritis

ICD Disease Classification

4A40.0Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Calcineurin (PPP3CA)	DTT	PPP3CA	5.29E-01	1.74E-03	9.99E-03

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
2	Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.