Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWPBKU)

Drug Name

N-methyllaurotetanine Drug Info

Synonyms

Lauroscholtzine; N-Methyllaurotetanine; 2169-44-0; Rogersine; NSC 247564; CHEMBL464099; UNII-11558LRZ50; NSC 247506; 11558LRZ50; 1,2,10-Trimethoxy-6a-alpha-aporphin-9-ol; 6a-alpha-APORPHIN-9-OL, 1,2,10-TRIMETHOXY-; 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (S)-; Boldine 2-methyl ether; (+)-N-methyl-laurotetanine; AC1L288L; DTXSID60176073; MolPort-003-804-060; ZINC338123; NSC247506; BDBM50250422; NSC247564; AKOS032948666; NSC-247564; NSC-247506; LS-21503; W1151

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16573
CAS Number: CAS 2169-44-0
TTD Drug ID: DMWPBKU

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in ... J Nat Prod. 2006 Mar;69(3):432-5.