Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWQIJX)

Drug Name

Celastrol Drug Info

Synonyms

Tripterin; Tripterine; Celastrol, Celastrus scandens; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid

Indication

Disease Entry	ICD 11	Status	REF
Motor neurone disease	8B60	Preclinical	[1]

Cross-matching ID

PubChem CID: 122724
ChEBI ID: CHEBI:63959
CAS Number: CAS 34157-83-0
TTD Drug ID: DMWQIJX

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 beta (IL1B)	TTRYK0X	IL1B_HUMAN	Suppressor	[1]
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Suppressor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Interleukin-1 beta (IL1B)	DTT	IL1B	6.757	6.019	6.475	7.026
Tumor necrosis factor (TNF)	DTT	TNF	5.692	3.07	4.413	1.202

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Motor neurone disease

ICD Disease Classification

8B60

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Interleukin-1 beta (IL1B)	DTT	IL1B	4.74E-01	8.78E-03	0.02

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.