Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWUFQ4)

Drug Name

Ramucirumab Drug Info

Synonyms

LY3009806

Indication

Disease Entry	ICD 11	Status	REF
Gastric adenocarcinoma	2B72	Approved	[1]
Bladder cancer	2C94	Phase 3	[2]
Hepatocellular carcinoma	2C12.02	Phase 3	[2]
Non-small-cell lung cancer	2C25.Y	Phase 3	[2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Modulator	[3]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Gastric adenocarcinoma

ICD Disease Classification

2B72

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 2 (KDR)	DTT	KDR	1.98E-01	0.11	0.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7390).
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.