Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXACM2)

Drug Name

Anti-RON receptor mabs Drug Info

Synonyms

AV-368 series; Hu-07F01; Hu-29B06; Anti-RON receptor mAbs (cancer); Anti-RON receptor mAbs (cancer), AVEO Pharmaceuticals; Anti-RON receptor mAbs (cancer), Centocor Ortho Biotech

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMXACM2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Macrophage-stimulating protein receptor (RON)	TTBQ3OC	RON_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Macrophage-stimulating protein receptor (RON)	DTT	MST1R	5.771	6.624	5.779	7.751

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Macrophage-stimulating protein receptor (RON)	DTT	MST1R	1.59E-01	-0.03	-0.23

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1816).