Details of the Drug

General Information of Drug (ID: DMXACM2)

Drug Name
Anti-RON receptor mabs
Synonyms AV-368 series; Hu-07F01; Hu-29B06; Anti-RON receptor mAbs (cancer); Anti-RON receptor mAbs (cancer), AVEO Pharmaceuticals; Anti-RON receptor mAbs (cancer), Centocor Ortho Biotech
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Drug Type
Antibody
Cross-matching ID
TTD ID
D07PWY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Macrophage-stimulating protein receptor (RON) TTBQ3OC RON_HUMAN Not Available [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Macrophage-stimulating protein receptor (RON) DTT MST1R 1.59E-01 -0.03 -0.23
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1816).
2 MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.