Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXANES)

Drug Name

N-Phenylbenzo[d]oxazol-2-amine Drug Info

Synonyms

N-phenyl-1,3-benzoxazol-2-amine; 2-benzoxazolamine, n-phenyl-; MLS000564967; CHEMBL1269508; SMR000152172; N-Phenylbenzo[d]oxazol-2-amine; NSC53097; 2-anilinobenzoxazole; Enamine_001986; AC1L6BGG; AC1Q4WEW; 2-(Phenylamino)benzoxazole; Oprea1_506735; Oprea1_258700; cid_243391; SCHEMBL2658434; BDBM49481; BFLIOKCEGCUTNH-UHFFFAOYSA-N; HMS2433J13; HMS1399K06; 1,3-benzoxazol-2-yl(phenyl)amine; ZINC1684315; NSC-53097; BENZOOXAZOL-2-YL-PHENYL-AMINE; AKOS003001295; SC-56852; KB-302380; N-phenyl-2,3-dihydro-1,3-benzoxazol-2-imine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 243391
CAS Number: CAS 6631-42-1
TTD Drug ID: DMXANES

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. Bioorg Med Chem. 2010 Nov 1;18(21):7580-5.