Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXJOYH)

Drug Name

DOM-0215 Drug Info

Synonyms

dual anti-TNFalpha/unspecified target human dAb (rheumatoid arthritis), Domantis; dual-targeting domain antibody therapy (rheumatoid arthritis), Domantis

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMXJOYH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Tumor necrosis factor (TNF)	DTT	TNF	5.692	3.07	4.413	1.202

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tumor necrosis factor (TNF)	DTT	TNF	8.51E-01	0.05	0.27

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.