Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXU2GS)

Drug Name

SBS-1000 Drug Info

Synonyms

PrInsulin; Diabetes therapy, SemBioSys; Human insulin (safflower), SemBioSys; Plant-derived insulin (diabetes), SemBioSys; Safflower seed-derived human insulin (diabetes), SemBioSys

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMXU2GS

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin (INS)	TTZOPHG	INS_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Insulin (INS)	DTT	INS	0.848	2.138	0.379	0.926

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Insulin (INS)	DTT	INS	6.70E-01	-0.12	-0.46

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study. Clin Exp Immunol. 2009 Feb;155(2):156-65.
2	Synergistic antihyperglycemic effects between plant-derived oleanolic acid and insulin in streptozotocin-induced diabetic rats. Ren Fail. 2010;32(7):832-9.