Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMY293M)

Drug Name

PEG-LPA-2 Drug Info

Synonyms

Leptin receptor antagonists (cancer/endometriosis); Leptin receptor antagonists (cancer/endometriosis), CRT; Leptin receptor antagonists (cancer/endometriosis), Cancer Research Technology; PEGylated leptin receptor antagonists (cancer/endometriosis), CRT; PEGylated leptin receptor antagonists (cancer/endometriosis), Cancer Research Technology

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMY293M

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leptin receptor (LEPR)	TT0HD6V	LEPR_HUMAN	Antagonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Leptin receptor (LEPR)	DTT	LEPR	8.131	5.561	5.776	5.3

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Leptin receptor (LEPR)	DTT	LEPR	5.82E-02	0.05	0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1712).