Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYHSO2)

Drug Name
ABT-874 Drug Info
Indication
Disease Entry ICD 11 Status REF
Plaque psoriasis EA90.0 Phase 3 [1]
Rheumatoid arthritis FA20 Phase 1 [1]
Crohn disease DD70 Discontinued in Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMYHSO2

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin-12 beta (IL12B) TTGW72V IL12B_HUMAN Modulator [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 15 Disease of the musculoskeletal system/connective tissue
Disease Class ICD-11: FA20 Rheumatoid arthritis
The Studied Tissue Synovial tissue
The Studied Disease Rheumatoid arthritis [ICD-11:FA20]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin-12 beta (IL12B) DTT IL12B 9.01E-01 1.32E-02 0.07
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
2 Briakinumab for the treatment of plaque psoriasis.BioDrugs.2012 Feb 1;26(1):9-20.