Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYMNBL)

Drug Name

Phenyl-phosphonic acid Drug Info

Synonyms

Phenylphosphonic acid; 1571-33-1; Benzenephosphonic acid; Phosphonic acid, phenyl-; PHENYL PHOSPHONIC ACID; Phosphonic acid, P-phenyl-; UNII-BYD76T2868; NSC 145; EINECS 216-388-1; BRN 2245168; Phenylphosphonic acid, 98%; AI3-52844; NSC145; CHEMBL179801; QLZHNIAADXEJJP-UHFFFAOYSA-N; BYD76T2868; C6H7O3P; SV7; PubChem21303; Phosphonic acid,phenyl-; Dihydrogen phenylphosphonate; AC1L25LB; NCIStruc2_000427; NCIStruc1_000503; ACMC-1C27E; DSSTox_CID_24399; DSSTox_RID_80200; SCHEMBL34998

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15295
CAS Number: CAS 1571-33-1
TTD Drug ID: DMYMNBL

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase IV (CA-IV)	DTT	CA4	1.58E-77	-2.02	-1.77
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.