Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYQZBT)

Drug Name

MR-889 Drug Info

Synonyms

Midesteine; Midesteine [INN]; Midesteinum [INN-Latin]; Midesteina [INN-Spanish]; MR-889; 94149-41-4; MR 889; CHEMBL1808549; 2-(Thiophen-2-ylcarbonylthio)-N-(2-oxo-2,3,4,5-tetrahydrothiophen-3-yl)propionamide; 2-Thiophenecarbothioic acid, S-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester; C12H13NO3S3; Midesteinum; Midesteina; 2-Thiophenecarbothioic acid, S-ester with (+-)-2-mercapto-N-(tetrahydro-2-oxo-3-thienyl)propionamide; SCHEMBL724755; AC1L242H; CTK3I7550; MR889; BDBM50349435; SB19618; LS-152918

Indication

Disease Entry	ICD 11	Status	REF
Phlegmy cough	SA80-SA8Z	Discontinued in Phase 3	[1]

Cross-matching ID

PubChem CID: 65837
CAS Number: CAS 94149-41-4
TTD Drug ID: DMYQZBT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Neutrophil elastase (NE)	DTT	ELANE	2.379	2.036	1.379	2.945

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Phlegmy cough

ICD Disease Classification

SA80-SA8Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Neutrophil elastase (NE)	DTT	ELANE	2.35E-01	-0.55	-0.82

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003709)
2	Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.