Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ43N1)

• Drug Name: N-adamantyl-N'-cyclohexylurea Drug Info
• Synonyms: CHEMBL242255; N-1-adamantyl-N'-cyclohexylurea; AC1NMPQQ; Urea-based compound, 13; ChemDiv3_000178; Oprea1_419513; 1-adamantyl-3-cyclohexylurea; MLS000719875; SCHEMBL653168; BDBM25732; MolPort-003-713-177; HMS2616F12; HMS1473I02; 3-adamantan-1-yl-1-cyclohexylurea; 1-(1-adamantyl)-3-cyclohexylurea; ZINC3895072; AKOS001483388; MCULE-6291906995; 1-(Adamantane-1-yl)-3-cyclohexylurea; IDI1_019496; N-adamantanyl(cyclohexylamino)carboxamide; NCGC00177652-01; SMR000304404; EU-0000129; ST51030996; US8815951, 192; SR-01000389488

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5029871
  TTD Drug ID: DMZ43N1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Soluble epoxide hydrolase (EPHX2)	TT7WVHI	HYES_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Soluble epoxide hydrolase (EPHX2)	DTT	EPHX2	8.353	7.227	6.421	8.192

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Soluble epoxide hydrolase (EPHX2)	DTT	EPHX2	8.78E-01	-0.1	-0.27
Soluble epoxide hydrolase (EPHX2)	DTT	EPHX2	4.40E-02	-0.18	-0.42

References

• [1] Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem. 2007 Aug 9;50(16):3825-40.