Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ5ISH)

Drug Name

Imidazolidin-2-ylidene-quinoxalin-6-yl-amine Drug Info

Synonyms

91147-43-2; CHEMBL49395; Brimonidine impurity II; 6-Quinoxalinamine, N-(4,5-dihydro-1H-imidazol-2-yl)-; SCHEMBL679239; N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine; SCHEMBL12860178; ZINC14042; CTK3I1267; DTXSID00436663; MolPort-039-240-453; N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-QUINOXALINAMINE; BDBM50213029; N-quinoxalin-6-ylimidazolidin-2-imine; AKOS030240596

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10198248
CAS Number: CAS 91147-43-2
TTD Drug ID: DMZ5ISH

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1B (ADRA1B)	TTBRKXS	ADA1B_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).