Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZAMNX)

Drug Name
Peptide analog 59 Drug Info
Synonyms PMID26118988-Compound-14
Cross-matching ID
TTD Drug ID
DMZAMNX

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin G (CTSG) TTQAJF1 CATG_HUMAN Inhibitor [1]
Neutrophil elastase (NE) TTPLTSQ ELNE_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cathepsin G (CTSG) DTT CTSG 4.293 5.031 4.65 4.781
Neutrophil elastase (NE) DTT ELANE 2.379 2.036 1.379 2.945
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cathepsin G (CTSG) DTT CTSG 8.23E-01 0.23 0.26
Cathepsin G (CTSG) DTT CTSG 5.14E-01 0.05 0.19
Neutrophil elastase (NE) DTT ELANE 9.42E-01 0.02 0.07
Neutrophil elastase (NE) DTT ELANE 1.43E-02 0.05 0.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58.