General Information of Drug (ID: DMZGCEQ)

Drug Name
1,2,3,4-tetrahydroisoquinoline Drug Info
Synonyms
1,2,3,4-Tetrahydroisoquinoline; 91-21-4; Tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-isoquinoline; ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-; 1,2,3,4-Tetrahydro isoquinoline; EINECS 202-050-0; NSC 15312; 1,2,3,4-Tetrahydro-2-isoquinoline; 1,2,3,4-Tetrahydro-2-azanaphthalene; BRN 0116156; UNII-56W89FBX3E; CHEMBL14346; AI3-15931; 56W89FBX3E; UWYZHKAOTLEWKK-UHFFFAOYSA-N; MFCD00006896; 1,2,3,4-Tetrahydroisoquinoline, 95%; 3,4-dihydro-1H-isoquinoline; tetrahydroisoquinolin; tetrahyroisoquinoline; tetrahydro-isoquinoline; PubChem7253; AC1L1NVS
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7046
ChEBI ID
CHEBI:125498
CAS Number
CAS 91-21-4
TTD Drug ID
DMZGCEQ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor alpha-2A (ADRA2A) TTWG9A4 ADA2A_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2B (ADRA2B) TTWM4TY ADA2B_HUMAN Inhibitor [1]
Adrenergic receptor alpha-2C (ADRA2C) TT2NUT5 ADA2C_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 5.013 2.379 5.594 2.07
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Adrenergic receptor alpha-2C (ADRA2C) DTT ADRA2C 1.76E-01 -0.06 -0.28
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33.