Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZH0K8)

Drug Name

JNJ-10392980 Drug Info

Synonyms

841200-46-2; benzoxazole,2-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-; JNJ-10392980; Benzoxazole compound, 10b; CHEMBL481863; SCHEMBL2170316; BDBM24203; ZIQGASWXUSSORV-UHFFFAOYSA-N; ZINC36377694; KB-306080; 2-[4-(2-Piperidin-1-yl-ethoxy)-phenoxy]-benzooxazole

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11739248
TTD Drug ID: DMZH0K8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
Leukotriene A-4 hydrolase (LTA4H)	TTXZEAJ	LKHA4_HUMAN	Inhibitor	[1]
Voltage-gated potassium channel Kv11.1 (KCNH2)	TTQ6VDM	KCNH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Leukotriene A-4 hydrolase (LTA4H)	DTT	LTA4H	7.338	7.827	8.134	8.612
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
Voltage-gated potassium channel Kv11.1 (KCNH2)	DTT	KCNH2	4.805	7.656	5.272	6.452

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. J Med Chem. 2008 Jul 24;51(14):4150-69.