Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZIUQ2)

Drug Name

4-DAMP Drug Info

Synonyms

4-Diphenylacetoxy-1,1-dimethylpiperidinium; CHEMBL168067; 81405-11-0; CHEBI:73467; CHEMBL76897; 4-Damp methobromide; C21H26NO2; Tocris-0482; Lopac-D-104; AC1Q60WY; AC1L1C4C; 4-[(diphenylacetyl)oxy]-1,1-dimethylpiperidinium; Lopac0_000407; GTPL307; SCHEMBL2730650; 1952-15-4 (iodide); CTK3E9884; DTXSID70231086; 4-DAMP(1+); ZINC2555356; BDBM50176065; CCG-204500; NCGC00024611-02; NCGC00015304-04; NCGC00015304-03; NCGC00163244-01; NCGC00024611-01; NCGC00015304-02; NCGC00015304-01; LS-177624; N,N-dimethyl-4-(diphenylacetoxy)piperidinium

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3014059
ChEBI ID: CHEBI:73340
CAS Number: CAS 1952-15-4
TTD Drug ID: DMZIUQ2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M3 (CHRM3)	TTQ13Z5	ACM3_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M3 (CHRM3)	DTT	CHRM3	4.61E-07	-0.59	-0.73

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 307).
2	An increase in intracelluar free calcium ions modulated by cholinergic receptors in rat facial nucleus. Chin Med J (Engl). 2009 May 5;122(9):1049-55.