Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZKIE0)

Drug Name

Tolerimab Drug Info

Synonyms

Transplant rejection therapy, Innogenetics; MAbs (organ transplant), Innogenetics; Monoclonal antibodies (organ transplant), Innogenetics; ToleriMab (anti-B7.1/B7.2)

Indication

Disease Entry	ICD 11	Status	REF
Transplant rejection	NE84	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMZKIE0

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Activation B7-1 antigen (CD80)	TTFZDNP	CD80_HUMAN	Not Available	[2]
T-lymphocyte activation antigen CD86 (FUN1)	TTHGXBU	CD86_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
T-lymphocyte activation antigen CD86 (FUN1)	DTT	CD86	3.818	5.594	4.466	5.426
Activation B7-1 antigen (CD80)	DTT	CD80	6.576	6.711	6.951	6.944

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Transplant rejection

ICD Disease Classification

NE84

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Activation B7-1 antigen (CD80)	DTT	CD80	6.87E-07	-0.12	-0.3

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011393)
2	US patent application no. 2004,0171,123, Albumin fusion proteins.