Details of the Drug

General Information of Drug (ID: DMZKIE0)

Drug Name

Tolerimab

Synonyms

Transplant rejection therapy, Innogenetics; MAbs (organ transplant), Innogenetics; Monoclonal antibodies (organ transplant), Innogenetics; ToleriMab (anti-B7.1/B7.2)

Indication

Disease Entry	ICD 11	Status	REF
Transplant rejection	NE84	Terminated	[1]
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Drug Type

Antibody

Cross-matching ID

TTD ID: D0V4PH

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Activation B7-1 antigen (CD80)	TTFZDNP	CD80_HUMAN	Not Available	[2]
T-lymphocyte activation antigen CD86 (FUN1)	TTHGXBU	CD86_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Transplant rejection

ICD Disease Classification

NE84

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Activation B7-1 antigen (CD80)	DTT	CD80	6.87E-07	-0.12	-0.3

Molecular Expression Atlas (MEA)

MEA Detail

Jump to Detail Molecular Expression Atlas of This Drug

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011393)
2	US patent application no. 2004,0171,123, Albumin fusion proteins.