Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZTL7H)

Drug Name

T487 Drug Info

Synonyms

AC1MVK5U; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methyl-ethanamine; 2-(2,4-diethyloctoxy)-N-[2-(2,4-diethyloctoxy)ethyl]-N-methylethanamine

Indication

Disease Entry	ICD 11	Status	REF
Psoriatic disorder	EA90	Discontinued in Phase 2	[1]
Inflammation	1A00-CA43.1	Discontinued in Phase 1	[1]

Cross-matching ID

PubChem CID: 12896
ChEBI ID: CHEBI:75648
CAS Number: CAS 730-40-5
TTD Drug ID: DMZTL7H

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 3 (CXCR3)	TT1UCIJ	CXCR3_HUMAN	Antagonist	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
C-X-C chemokine receptor type 3 (CXCR3)	DTT	CXCR3	3.907	4.113	4.728	4.763

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Psoriatic disorder

ICD Disease Classification

EA90

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
C-X-C chemokine receptor type 3 (CXCR3)	DTT	CXCR3	1.68E-01	-0.24	-0.52

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of ChemoCentryx.
2	Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist. J Pharmacol Exp Ther. 2005 Jun;313(3):1263-71.