Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZUA5C)

Drug Name
MK-6302 Drug Info
Synonyms INS-20; Pegylated GCSF, Insmed/Merck
Indication
Disease Entry ICD 11 Status REF
Neutropenia 4B00.0 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMZUA5C

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Granulocyte colony-stimulating factor receptor (G-CSF-R) TTC70AJ CSF3R_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Granulocyte colony-stimulating factor receptor (G-CSF-R) DTT CSF3R 4.087 3.406 3.17 3.322
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Neutropenia
ICD Disease Classification 4B00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Granulocyte colony-stimulating factor receptor (G-CSF-R) DTT CSF3R 2.08E-08 0.36 0.96
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of Merck.
2 Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.