Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZV2PJ)

• Drug Name: Acetophenazine Drug Info
• Synonyms: Acephenazinum; Acetophenazina; Acetophenazinum; Tindal; Acetophenazine [INN]; Acetophenazina [INN-Spanish]; Acetophenazinum [INN-Latin]; Ketone, 10-(3-(4-(2-hydroxyethyl-1-piperazinyl)propyl)phenothiazin-2-yl methyl; 1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)ethanone; 1-[10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazin-2-yl]ethanone; 10-(3-(4-(2-Hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl methyl ketone; 2-acetyl-10-[3-[4-(b-hydroxyethyl)piperazinyl]propyl]phenothiazine

Indication

Disease Entry	ICD 11	Status	REF
Bipolar disorder	6A60	Approved	[1]

• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 17676
  ChEBI ID: CHEBI:2401
  CAS Number: CAS 2751-68-0
  TTD Drug ID: DMZV2PJ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Antagonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Dopamine D2 receptor (D2R)	DTT	DRD2	5.345	5.634	5.789	5.901

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Bipolar disorder
• ICD Disease Classification: 6A60

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Dopamine D2 receptor (D2R)	DTT	DRD2	2.50E-02	-0.08	-0.49

References

• [1] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 012254.
• [2] Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38.