Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZWIVJ)

Drug Name

N-hydroxy-2,3-bis(phenylsulfonamido)propanamide Drug Info

Synonyms

CHEMBL496717; N-hydroxy-2,3-bis(phenylsulfonamido)propanamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-21 (MMP-21)	TTYRF5E	MMP21_HUMAN	Inhibitor	[1]
Matrix metalloproteinase-7 (MMP-7)	TTMTWOS	MMP7_HUMAN	Inhibitor	[1]
Matrix metalloproteinase-9 (MMP-9)	TT6X50U	MMP9_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Matrix metalloproteinase-7 (MMP-7)	DTT	MMP7	5.567	5.479	9.387	2.766
Matrix metalloproteinase-9 (MMP-9)	DTT	MMP9	6.725	7.358	6.384	6.921

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Matrix metalloproteinase-7 (MMP-7)	DTT	MMP7	4.87E-01	-0.2	-0.57

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3333-7.