Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZY8UW)

Drug Name

4-Nitro-benzenesulfonamide Drug Info

Synonyms

4-NITROBENZENESULFONAMIDE; 6325-93-5; Benzenesulfonamide, 4-nitro-; p-Nitrobenzenesulfonamide; 4-Nitrobenzolesulfamide; p-Nitrophenylsulfonamide; 4-Nitrobenzenesulphonamide; Benzenesulfonamide, p-nitro-; 4-Nitro-benzenesulfonamide; UNII-TUF52O8Y8B; EINECS 228-691-6; NSC 31148; BRN 2214218; TUF52O8Y8B; CHEMBL282157; 4-Nitrobenzenesulfonamide, 97%; QWKKYJLAUWFPDB-UHFFFAOYSA-N; NsNH2; 4-nitrophenylsulfonamid; 3m8t; 4-Nitrobenzolsulfonamide; p-nitrophenyl sulfonamide; WLN: ZSWR DNW; p-nitrobenzene sulphonamide; AC1Q55AA; Cambridge id 5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 22784
CAS Number: CAS 6325-93-5
TTD Drug ID: DMZY8UW

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.