Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM01RZX)

Drug Name

QNZ 46 Drug Info

Synonyms

KB-275239

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glutamate receptor ionotropic NMDA 2D (GluN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[2]
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[2]
[3H]CPP	DMR5UBF	Discovery agent	N.A.	Investigative	[2]
2-Methylamino-succinic acid(NMDA)	DMKP6BM	Discovery agent	N.A.	Investigative	[2]
[3H]MDL105519	DMPKGHB	Discovery agent	N.A.	Investigative	[2]
[3H]CGP39653	DMITR7A	Discovery agent	N.A.	Investigative	[2]
homoquinolinic acid	DMBW5DU	Discovery agent	N.A.	Investigative	[2]
[3H]dizocilpine	DMEC2PF	Discovery agent	N.A.	Investigative	[2]
CGP61594	DM8KFZH	Discovery agent	N.A.	Investigative	[2]
(RS)-(tetrazol-5-yl)glycine	DMYZCRF	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 2D (GluN2D)	TT5POTG	NMDE4_HUMAN	Modulator (allosteric modulator)	[1]

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References

1	Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci. 2011 Mar 9;31(10):3650-61.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459).