Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM03I7V)

Drug Name

ERBULOZOLE Drug Info

Synonyms

Erbulozole < Rec INN; R-55104; Ethyl rac-cis-p-[[[2-(Imidazol-1-ylmethyl)-2-(p-methoxyphenyl)-1,3-dioxolan-4-yl]methyl]thio]carbanilate; Rac-cis-[4-[[2-((1H-Imidazol-1-ylmethyl)-2-(4-methoxyphenyl)-1,3-dioxolan-4-yl]methylthio]phenyl]carbamic acid ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 9934372
CAS Number: CAS 124784-31-2
TTD Drug ID: DM03I7V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Tubulin (TUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[3]
Vinorelbine	DMVXFYE	Advanced cancer	2A00-2F9Z	Approved	[4]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[5]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[6]
Ixabepilone	DM2OZ3G	Breast cancer	2C60-2C65	Approved	[5]
Eribulin	DM1DX4Q	Breast cancer	2C60-2C65	Approved	[5]
Epothilon	DMITJRU	Ovarian cancer	2C73	Phase 3	[7]
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
BMS-188797	DML1CK2	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
Indibulin	DM6OFJ8	Advanced sarcoma	2A60-2C35	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003227)
2	Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo. Eur J Cancer Clin Oncol. 1989 Oct;25(10):1499-504.
3	Docetaxel: a review of its use in metastatic breast cancer. Drugs. 2005;65(17):2513-31.
4	Vinca alkaloid and MDR1. Gan To Kagaku Ryoho. 2008 Jul;35(7):1086-9.
5	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
6	Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity. Biochemistry. 2009 Jul 28;48(29):6963-74.
7	Emerging drugs for ovarian cancer. Expert Opin Emerg Drugs. 2008 Sep;13(3):523-36.
8	Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15. J Med Chem. 1998 Apr 23;41(9):1524-30.
9	Phase I and pharmacokinetic study of BMS-188797, a new taxane analog, administered on a weekly schedule in patients with advanced malignancies. Clin Cancer Res. 2003 Nov 1;9(14):5187-94.
10	2011 Pipeline of ZioPharm.