Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM08F12)

Drug Name

KT6-971 Drug Info

Synonyms

Cholesterol absorption inhibitor, Kotobuki

Indication

Disease Entry	ICD 11	Status	REF
Hypercholesterolaemia	5C80.0	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Cholesterol absorption (Chole absorp)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MD-0727	DM5DSGJ	Hypercholesterolaemia	5C80.0	Phase 2	[3]
SCH-48461	DM28AFU	Hyperlipidaemia	5C80	Discontinued in Phase 2	[4]
Tiqueside	DMUJ2X6	Hyperlipidaemia	5C80	Discontinued in Phase 2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholesterol absorption (Chole absorp)	TTNA5ZS	NOUNIPROTAC	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032919)
2	Intestinal and Hepatic Niemann-Pick C1-Like 1. Correction in: Diabetes Metab J. 2013 December; 37(6): 486-487.
3	Th-P16:297 Early clinical characterization of MD-0727, a novel cholesterol absorption inhibitor, in healthy subjects. Atherosclerosis Supplements Volume 7, Issue 3, 2006, Pages 558-559.
4	Hypocholesterolemic activity of a novel inhibitor of cholesterol absorption, SCH 48461. Atherosclerosis. 1995 May;115(1):45-63.
5	Inhibiting cholesterol absorption with CP-88,818 (beta-tigogenin cellobioside; tiqueside): studies in normal and hyperlipidemic subjects. J Cardiovasc Pharmacol. 1997 Jul;30(1):55-60.