Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0EBAF)

Drug Name
dysiherbaine Drug Info
Synonyms
dysiherbaine; (2r,3ar,6s,7r,7ar)-2-[(2s)-2-Amino-2-Carboxyethyl]-6-Hydroxy-7-(Methylamino)hexahydro-2h-Furo[3,2-B]pyran-2-Carboxylic Acid; DYH; CHEMBL221142; GTPL4185; SCHEMBL12409079; BDBM85740; (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid (non-preferred name); (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)-hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9839436
TTD Drug ID
DM0EBAF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Glutamate receptor ionotropic kainate 2 (GRIK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [3]
SYM2081 DM30WDL Discovery agent N.A. Investigative [3]
domoic acid DMYPVO0 Discovery agent N.A. Investigative [3]
2,4-epi-neodysiherbaine DMZRY0Q Discovery agent N.A. Investigative [3]
Drug(s) Targeting Glutamate receptor ionotropic kainate 3 (GluK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [4]
SYM2081 DM30WDL Discovery agent N.A. Investigative [4]
UBP310 DMVQL3J Discovery agent N.A. Investigative [7]
Drug(s) Targeting Glutamate receptor ionotropic kainate 1 (GRIK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [8]
LY293558 DM4N6EK Pain MG30-MG3Z Phase 2 [9]
NS 1209 DM9EFH0 Epilepsy 8A60-8A68 Phase 2 [10]
NBQX DMPHZI5 Neurological disorder 6B60 Phase 1 [11]
YM-90K DMWRT4L Convulsion 8A68.Z Discontinued in Phase 2 [11]
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [2]
[3H]quisqualate DMDQBTX Discovery agent N.A. Investigative [12]
SYM2081 DM30WDL Discovery agent N.A. Investigative [2]
DNQX DMQXPA5 Discovery agent N.A. Investigative [13]
domoic acid DMYPVO0 Discovery agent N.A. Investigative [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Glutamate receptor ionotropic kainate 4 (GluK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [5]
SYM2081 DM30WDL Discovery agent N.A. Investigative [5]
domoic acid DMYPVO0 Discovery agent N.A. Investigative [5]
Drug(s) Targeting Glutamate receptor ionotropic kainate 5 (GRIK5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
[3H]kainate DMMK7XU Discovery agent N.A. Investigative [6]
SYM2081 DM30WDL Discovery agent N.A. Investigative [6]
domoic acid DMYPVO0 Discovery agent N.A. Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor ionotropic kainate 1 (GRIK1) TT0MYE2 GRIK1_HUMAN Agonist [2]
Glutamate receptor ionotropic kainate 2 (GRIK2) TT0K5RG GRIK2_HUMAN Agonist [3]
Glutamate receptor ionotropic kainate 3 (GluK3) TTNP6O2 GRIK3_HUMAN Agonist [4]
Glutamate receptor ionotropic kainate 4 (GluK4) TTQV6BO GRIK4_HUMAN Agonist [5]
Glutamate receptor ionotropic kainate 5 (GRIK5) TTO6LI7 GRIK5_HUMAN Agonist [6]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4185).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 450).
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 451).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 452).
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 453).
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 454).
7 Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310. Mol Pharmacol. 2010 Dec;78(6):1036-45.
8 Development of medications for alcohol use disorders: recent advances and ongoing challenges. Expert Opin Emerg Drugs. 2005 May;10(2):323-43.
9 Pharmacogenetics of new analgesics. Br J Pharmacol. 2011 Jun;163(3):447-60.
10 The efficacy of the AMPA receptor antagonist NS1209 and lidocaine in nerve injury pain: a randomized, double-blind, placebo-controlled, three-way crossover study. Anesth Analg. 2009 Apr;108(4):1311-9.
11 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7.
12 Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotr... J Med Chem. 2008 Jul 24;51(14):4093-103.
13 Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate recep... J Med Chem. 1996 Oct 25;39(22):4430-8.