Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0EWMT)

Drug Name

SRK-181 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Transforming growth factor beta 1 (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[3]
A435	DMJCL7X	Aggressive cancer	2A00-2F9Z	IND submitted	[4]
TG-C	DMLCXPD	Arthritis	FA20	Phase 3	[5]
LY2157299	DMP8HW1	Arteriosclerosis	BD40	Phase 2/3	[6]
Disitertide	DM2QBDS	Macular degeneration	9B78.3	Phase 2	[7]
ABBV-151	DMIQXDJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
ACE-1334	DMF1OUP	Systemic sclerosis	4A42	Phase 1	[9]
Mannose phosphate	DM1LM7D	Lesion	8A00-8C12	Discontinued in Phase 2	[10]
ART-144	DMEVT4I	Osteoarthritis	FA00-FA05	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transforming growth factor beta 1 (TGFB1)	TTR9XHZ	TGFB1_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04291079) SRK-181 Alone or in Combination With Anti-PD-(L)1 Antibody Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (DRAGON). U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Scholar Rock.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of Klus Pharma
5	Clinical pipeline report, company report or official report of Tissue Gene, Inc.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Perspectives of TGF-beta inhibition in pancreatic and hepatocellular carcinomas. Oncotarget. 2014 January; 5(1): 78-94.
8	Clinical pipeline report, company report or official report of AbbVie.
9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
10	The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101.
11	Pharmaceutical products of TORREYA partners. December 2011.