General Information of Drug (ID: DM1LM7D)

Drug Name
Mannose phosphate
Synonyms MANNOSE PHOSPHATE; SCHEMBL285569; SB17274
Indication
Disease Entry ICD 11 Status REF
Lesion 8A00-8C12 Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
1
Molecular Weight 278.15
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 5
Hydrogen Bond Donor Count 8
Hydrogen Bond Acceptor Count 10
Chemical Identifiers
Formula
C6H15O10P
IUPAC Name
(2S,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid
Canonical SMILES
C([C@H]([C@H]([C@@H]([C@@H](C=O)O)O)O)O)O.OP(=O)(O)O
InChI
InChI=1S/C6H12O6.H3O4P/c7-1-3(9)5(11)6(12)4(10)2-8;1-5(2,3)4/h1,3-6,8-12H,2H2;(H3,1,2,3,4)/t3-,4-,5-,6-;/m1./s1
InChIKey
NDVRKEKNSBMTAX-MVNLRXSJSA-N
Cross-matching ID
PubChem CID
73014169
TTD ID
D0U3DX

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Transforming growth factor beta 1 (TGFB1) TTR9XHZ TGFB1_HUMAN Modulator [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Lesion
ICD Disease Classification 8A00-8C12
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Transforming growth factor beta 1 (TGFB1) DTT TGFB1 5.95E-09 1.68 7.81
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS One. 2014 Oct 14;9(10):e110345.
2 The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101.