Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0GJVS)

Drug Name

SPONGIADIOXIN A Drug Info

Synonyms

SPONGIADIOXIN A; CHEMBL185828; 329040-77-9; Dibenzo[b,e][1,4]dioxin-1-ol, 3,4,6,8-tetrabromo-; BDBM50150784

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[2]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[3]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[3]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[3]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[3]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[3]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[3]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[3]
NSC-661755	DMDJT7U	N. A.	N. A.	Terminated	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.
2	Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
3	15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
4	Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
5	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.