Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0OX31)

Drug Name

Glypromate Drug Info

Synonyms

Glypromate; Glycyl-prolyl-glutamic acid; Gly-Pro-Glu, >=98% (HPLC); Gly-pro-glu; SCHEMBL1170125; ZINC3776571; ZYK4RVV5LS; glycyl-l-prolyl-l-glutamic acid; 32302-76-4; CHEMBL371315; DB05633; DTXSID80186038; UNII-ZYK4RVV5LS

Indication

Disease Entry	ICD 11	Status	REF
Neurological disorder	6B60	Discontinued in Phase 2	[1]

Cross-matching ID

PubChem CID: 3080768
CAS Number: CAS 32302-76-4
TTD Drug ID: DM0OX31
INTEDE Drug ID: DR2723

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting PI3K/AKT/mTOR pathway (PAm pathway)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[4]
ON-01210.Na	DMWYEDX	Acute radiation syndrome	NF00	Phase 1	[5]
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Drug(s) Metabolized By Tripeptidase (pepT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZETIRELIN	DMLY9F1	Pain	MG30-MG3Z	Phase 3	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PI3K/AKT/mTOR pathway (PAm pathway)	TTGQUFK	NOUNIPROTAC	Modulator	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Tripeptidase (pepT)^{Main DME}	DEIZ2D9	PEPT_LACLL	Substrate	[3]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021881)
2	Dendritic spine dysgenesis in Rett syndrome. Front Neuroanat. 2014; 8: 97.
3	Tripeptidase gene (pepT) of Lactococcus lactis: molecular cloning and nucleotide sequencing of pepT and construction of a chromosomal deletion mutant. J Bacteriol. 1994 May;176(10):2854-61.
4	The genomic landscape of nasopharyngeal carcinoma.Nat Genet. 2014 Aug;46(8):866-71.
5	ON01210.Na (Ex-RAD ) mitigates radiation damage through activation of the AKT pathway. PLoS One. 2013;8(3):e58355.
6	Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm Res. 1997 Aug;14(8):1004-7.