General Information of Drug (ID: DM0PETL)

Drug Name
SB-525334 Drug Info
Synonyms
356559-20-1; SB 525334; SB-525334; SB525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; 6-[2-TERT-BUTYL-5-(6-METHYL-PYRIDIN-2-YL)-1H-IMIDAZOL-4-YL]-QUINOXALINE; CHEMBL401570; 6-[2-(1,1-DiMethylethyl)-5-(6-Methyl-2-pyridinyl)-1H-iMidazol-4-yl]quinoxaline; C21H21N5; 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline; 6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; MLS006011134; SCHEMBL373474; QCR-68; SCHEMBL10000768; CTK4H5088; CHEBI:91391; AOB5969
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
9967941
ChEBI ID
CHEBI:91391
CAS Number
CAS 356559-20-1
TTD Drug ID
DM0PETL

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LY2157299 DMP8HW1 Arteriosclerosis BD40 Phase 2/3 [2]
TEW-7197 DM2LBC3 Myeloproliferative neoplasm 2A20 Phase 2 [3]
Metelimumab DMENFD6 Scleroderma 4A42 Phase 1/2 [4]
TP-0184 DMJVZBC Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
P-2745 DMJ3PNS Chronic myelogenous leukaemia 2A20.0 Phase 1 [6]
LY3200882 DMQP6VB Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
PF-06952229 DMDQJEZ Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
SB-431542 DM0YOXQ Pulmonary fibrosis CB03.4 Preclinical [9]
SM-16 DMHXJV2 Fibrosis GA14-GC01 Terminated [10]
LF-984 DMIYMS2 Fibrosis GA14-GC01 Terminated [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TGF-beta receptor type I (TGFBR1) TTP4520 TGFR1_HUMAN Inhibitor [1]

References

1 Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors, Bioorg. Med. Chem. Lett. 20(14):4228-4232 (2010).
2 Cardiac Safety of TGF-beta Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study. Cardiovasc Toxicol. 2015 Oct;15(4):309-23.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004 Dec;3(12):1011-22.
5 Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma.
6 Novel potent inhibitor of Bcr-Abl mutated imatinib resistant chronic myeloid leukemia cell lines. Cancer Research. 06/2012; 72(8 Supplement):1822-1822.
7 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8 Targeting the TGF pathway for cancer therapy. Pharmacol Ther. 2015 Mar;147:22-31.
9 Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9.
10 TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol. 2007 Feb;19(2):117-26.
11 US patent application no. 2013,0028,978, Compositions and methods for wound treatment.