Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0QV27)

• Drug Name: NN5401 Drug Info
• Synonyms: Insulin degludec and insulin aspart; Ryzodeg (TN)

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Phase 3	[1]

• Cross-matching ID: TTD Drug ID: DM0QV27

Molecule-Related Drug Atlas

Drug(s) Targeting Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[3]
Human neutral insulin	DMA5OBU	Diabetic complication	5A2Y	Approved	[4]
Insulin Lyspro recombinant	DM5XHVR	Diabetic complication	5A2Y	Approved	[4]
Insulin, porcine	DMO95XI	Diabetic complication	5A2Y	Approved	[5]
Insulin recombinant	DMYVP5G	Diabetic complication	5A2Y	Approved	[4]
Metformin arginine-hemisuccinimide	DMTPAM3	Type-2 diabetes	5A11	Approved	[6]
Insulin-lispro	DM4O90W	Diabetic complication	5A2Y	Approved	[7]
Insulin-glulisine	DMQI0FU	Diabetic complication	5A2Y	Approved	[8]
Ryzodeq	DMOFP18	Type-2 diabetes	5A11	Approved	[2]
Metformin glycinate	DMFE0P1	Type-2 diabetes	5A11	Phase 2/3	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin receptor (INSR)	TTCBFJO	INSR_HUMAN	Modulator	[2]

References

• [1] ClinicalTrials.gov (NCT01059812) A Pan Asian Trial Comparing Efficacy and Safety of NN5401 and Biphasic Insulin Aspart 30 in Type 2 Diabetes. U.S. National Institutes of Health.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800).
• [3] New drugs for type 2 diabetes mellitus: what is their place in therapy Drugs. 2008;68(15):2131-62.
• [4] Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
• [5] Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor. J Biochem. 2002 Jun;131(6):855-9.
• [6] Metformin (Glucophage) inhibits tyrosine phosphatase activity to stimulate the insulin receptor tyrosine kinase. Biochem Pharmacol. 2004 Jun 1;67(11):2081-91.
• [7] Hope for insulin mimetic oral antidiabetic drugs. Eur J Endocrinol. 1999 Dec;141(6):561-2.
• [8] Insulin glulisine: a review of its use in the management of diabetes mellitus. Drugs. 2009;69(8):1035-57.
• [9] Effect of Metformin Glycinate on Glycated Hemoglobin A1c Concentration and Insulin Sensitivity in Drug-Naive Adult Patients with Type 2 Diabetes Mellitus. Diabetes Technol Ther. 2012 December; 14(12): 1140-1144.