General Information of Drug (ID: DM0RZDF)

Drug Name
MCP-204 Drug Info
Synonyms Delta opioid receptor agonist (urology therapy/neuropathic pain), Mt Cook Pharma
Indication
Disease Entry ICD 11 Status REF
Bladder disease DC11-DC1Z Investigative [1]
Cross-matching ID
TTD Drug ID
DM0RZDF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Codeine DMJX6ZG Allergic rhinitis CA08.0 Approved [2]
Hydromorphone DMHP21E Back pain ME84.Z Approved [3]
Loperamide DMOJZQ9 Diarrhea ME05.1 Approved [4]
Eluxadoline DMYZ0P1 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [5]
Oxycodone DMXLKHV Osteoarthritis FA00-FA05 Approved [6]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [2]
Carfentanil DM7ADGX N. A. N. A. Phase 2 [7]
Met-enkephalin DMSZFTP Pain MG30-MG3Z Phase 2 [8]
AZD-2327 DM8FZOG Anxiety disorder 6B00-6B0Z Phase 2 [9]
ADL-5747 DMMUPTN Pain MG30-MG3Z Phase 2 [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Opioid receptor delta (OPRD1) TT27RFC OPRD_HUMAN Agonist [1]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).
2 Butorphanol: effects of a prototypical agonist-antagonist analgesic on kappa-opioid receptors. J Pharmacol Sci. 2005 Jun;98(2):109-16.
3 Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. J Med Chem. 2004 Mar 11;47(6):1400-12.
4 Loperamide: evidence of interaction with mu and delta opioid receptors. Life Sci. 1983;33 Suppl 1:315-8.
5 Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.Biochem Pharmacol.2014 Dec 1;92(3):448-56.
6 Oxycodone: a pharmacological and clinical review. Clin Transl Oncol. 2007 May;9(5):298-307.
7 Wax PM, Becker CE, Curry SC: Unexpected gas casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5.
8 Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon. Eur J Pharmacol. 1994 Sep 1;262(1-2):33-9.
9 Preclinical pharmacology of AZD2327: a highly selective agonist of the delta-opioid receptor. J Pharmacol Exp Ther. 2011 Jul;338(1):195-204.