Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM129VT)

Drug Name

514G3 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Staphylococcus infection	1B5Y	Phase 1/2	[1]

Cross-matching ID

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus IgG binding protein A (Stap-coc SpA)	TTOWKQ9	SPA_STAA8	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT02357966) A Study of the Safety and Efficacy of 514G3 in Subjects Hospitalized With Bacteremia Due to Staphylococcus Aureus. U.S. National Institutes of Health.
2	A natural human monoclonal antibody targeting Staphylococcus Protein A protects against Staphylococcus aureus bacteremia. PLoS One. 2018 Jan 24;13(1):e0190537.