General Information of Drug (ID: DM15LAP)

Drug Name
Fonsartan Drug Info
Synonyms HR-720; Hoe-720
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
11585346
TTD Drug ID
DM15LAP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ANGIOTENSIN II DMLWQ27 Increase blood pressure BA04 Approved [3]
SARALASIN DMKS1DV Hypertension BA00-BA04 Approved [4]
EMA-401 DMYOUB6 Peripheral neuropathy 8C0Z Phase 2 [5]
MP-157 DM5VXWO Hypertension BA00-BA04 Phase 1 [6]
PMID25416646-Compound-Figure5-E DMYO7VH N. A. N. A. Patented [7]
Phenylpyridine derivative 3 DMDT5JI N. A. N. A. Patented [7]
1-(biphenyl-4-yl-methyl)-1H-imidazole derivative 1 DMGYZQ2 N. A. N. A. Patented [7]
L-158282 DMKSEIY N. A. N. A. Discontinued in Phase 2 [8]
TAK-591 DM25DB4 Hypertension BA00-BA04 Discontinued in Phase 1 [9]
L-159689 DM9JE7Y Hypertension BA00-BA04 Terminated [10]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin II receptor type-2 (AGTR2) TTQVOEI AGTR2_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005209)
2 Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J Hypertens. 1998 Dec;16(12 Pt 2):2039-43.
3 The preparation of (perfluoroalkyl)imidazoles as nonpeptide angiotensin II receptor antagonists, Bioorg. Med. Chem. Lett. 3(5):895-898 (1993).
4 cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain... J Med Chem. 2008 Nov 27;51(22):7094-8.
5 Clinical pipeline report, company report or official report of Spinifex.
6 As drug target reemerges, the question is to block or stimulate it. Nature Medicine. Spoonful of Medicine. 05 Feb 2014. Cassandra Willyard
7 PPAR ligands and their therapeutic applications: a patent review (2008 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):175-91.
8 Subtituted phenylthiophene benzoylsulfonamides with potent binding affinity to angiotensin II AT1 and AT2 receptors, Bioorg. Med. Chem. Lett. 4(1):189-194 (1994).
9 Clinical pipeline report, company report or official report of Takeda (2009).
10 The design, binding affinity prediction and synthesis of macrocyclic angiotensin II AT1 and AT2 receptor antagonists, Bioorg. Med. Chem. Lett. 6(8):923-928 (1996).