General Information of Drug (ID: DM180DM)

Drug Name
ARGX-113 Drug Info
Indication
Disease Entry ICD 11 Status REF
Myasthenia gravis 8C6Y Phase 3 [1]
Cross-matching ID
TTD Drug ID
DM180DM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Efgartigimod alfa DM2M93X Myasthenia gravis 8C6Y Approved [3]
Batoclimab DMYPMR8 Myasthenia gravis 8C6Y Phase 3 [4]
Nipocalimab? DM0DYAX Chronic inflammatory demyelinating polyneuropathy 8C01.3 Phase 3 [5]
SYN-1327 DMFNR75 Discovery agent N.A. Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neonatal Fc receptor (FCGRT) TTKLPHO FCGRN_HUMAN Antagonist [2]

References

1 ClinicalTrials.gov (NCT03770403) A Safety and Tolerability Study of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness. (ADAPT+). U.S. National Institutes of Health.
2 Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis. Neurology. 2019 Jun 4;92(23):e2661-e2673.
3 FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 761195.
4 Batoclimab as an add-on therapy in neuromyelitis optica spectrum disorder patients with acute attacks. Eur J Neurol. 2023 Jan;30(1):195-203.
5 New Therapies for the Treatment of Warm Autoimmune Hemolytic Anemia. Transfus Med Rev. 2022 Oct;36(4):175-180.
6 Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem. 2008 Jun 15;16(12):6394-405.