General Information of Drug (ID: DM19D7G)

Drug Name
PMID22686657C(R)-26 Drug Info
Synonyms GTPL6535; BDBM50392215
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
60148519
TTD Drug ID
DM19D7G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug(s) Targeting Cathepsin S (CTSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7625 DMDGPKS Autoimmune disease 4A40-4A45 Phase 2 [2]
SAR-114137 DMZ1XR5 Pain MG30-MG3Z Phase 1 [3]
VBY- 891 DMTKPH4 Autoimmune diabetes 5A10 Phase 1 [4]
VBY- 036 DMULRYC Neuropathic pain 8E43.0 Phase 1 [5]
VBY-129 DM4YIWK Autoimmune diabetes 5A10 Phase 1 [6]
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [7]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [7]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [7]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [8]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Cathepsin F (CTSF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [7]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [7]
WRR-99 DM8ZA6K Discovery agent N.A. Investigative [9]
Benzoyl-Arginine-Alanine-Methyl Ketone DMC7TNF Discovery agent N.A. Investigative [9]
WRR-112 DMP761U Discovery agent N.A. Investigative [9]
HOMOPHENYLALANINYLMETHANE DMVBTHA Discovery agent N.A. Investigative [10]
BENZOYL-TYROSINE-ALANINE-METHYL KETONE DMIRD8S Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin F (CTSF) TTJOKD1 CATF_HUMAN Inhibitor [1]
Cathepsin S (CTSS) TTUMQVO CATS_HUMAN Inhibitor [1]

References

1 Selective nitrile inhibitors to modulate the proteolytic synergism of cathepsins S and F. J Med Chem. 2012 Jun 28;55(12):5982-6.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
5 Clinical pipeline report, company report or official report of ViroBay.
6 Clinical pipeline report, company report or official report of ViroBay.
7 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
8 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.
9 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
10 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.