Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM19NAI)

Drug Name

Alpha-Sulfanylpropylphosphonic acid Drug Info

Synonyms

SCHEMBL2530501

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Staphylococcus Beta-lactamase (Stap-coc blaZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tazobactam	DM3XNUI	Bacterial infection	1A00-1C4Z	Approved	[2]
Ceftolozane/tazobactam	DM9QWAH	Discovery agent	N.A.	Approved	[3]
Meropenem + vaborbactam	DMOVAIX	Intra-abdominal infection	1A40	Approved	[4]
Clavulanate	DM2FGRT	Bacterial infection	1A00-1C4Z	Approved	[5]
CAZ AVI	DMPG4OM	Serious infection	1H0Z	Phase 3	[6]
Enmetazobactam	DMZKTYJ	Urinary tract infection	GC08	Phase 3	[7]
Vaborbactam	DMDCFXJ	Urinary tract infection	GC08	Phase 3	[8]
MK-7655	DMLMV0O	Bacterial infection	1A00-1C4Z	Phase 2	[9]
CXL	DM3JFZ2	Methicillin-resistant staphylococci infection	1A00-1A09	Phase 2	[10]
RASV-Sp	DM4VTX6	Streptococcus infection	1B53	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Beta-lactamase (Stap-coc blaZ)	TTHI19T	BLAC_STAAU	Inhibitor	[1]

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References

1	Mercaptophosphonate compounds as broad-spectrum inhibitors of the metallo-beta-lactamases. J Med Chem. 2010 Jul 8;53(13):4862-76.
2	Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay. N Biotechnol. 2009 Nov 30;26(5):251-9.
3	2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
4	2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
5	A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors. Assay Drug Dev Technol. 2009 Apr;7(2):170-9.
6	NXL104 irreversibly inhibits the -lactamase from Mycobacterium tuberculosis. Biochemistry. 2012 Jun 5;51(22):4551-7.
7	Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum--Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20.
8	Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01443-17.
9	Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin . Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5.
10	Beta-Lactam Antibiotics Renaissance. Antibiotics. 2014, 3(2), 193-215.
11	WO patent application no. 2010,0456,20, Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae.