Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1LM7D)

Drug Name

Mannose phosphate Drug Info

Synonyms

MANNOSE PHOSPHATE; SCHEMBL285569; SB17274

Indication

Disease Entry	ICD 11	Status	REF
Lesion	8A00-8C12	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Transforming growth factor beta 1 (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[3]
A435	DMJCL7X	Aggressive cancer	2A00-2F9Z	IND submitted	[4]
TG-C	DMLCXPD	Arthritis	FA20	Phase 3	[5]
LY2157299	DMP8HW1	Arteriosclerosis	BD40	Phase 2/3	[6]
Disitertide	DM2QBDS	Macular degeneration	9B78.3	Phase 2	[7]
SRK-181	DM0EWMT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
ABBV-151	DMIQXDJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
ACE-1334	DMF1OUP	Systemic sclerosis	4A42	Phase 1	[10]
ART-144	DMEVT4I	Osteoarthritis	FA00-FA05	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transforming growth factor beta 1 (TGFB1)	TTR9XHZ	TGFB1_HUMAN	Modulator	[2]

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References

1	Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity. PLoS One. 2014 Oct 14;9(10):e110345.
2	The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-beta1 pathway in human lung fibroblasts. Immunol Lett. 2015 Jun;165(2):90-101.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of Klus Pharma
5	Clinical pipeline report, company report or official report of Tissue Gene, Inc.
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Perspectives of TGF-beta inhibition in pancreatic and hepatocellular carcinomas. Oncotarget. 2014 January; 5(1): 78-94.
8	Clinical pipeline report, company report or official report of Scholar Rock.
9	Clinical pipeline report, company report or official report of AbbVie.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
11	Pharmaceutical products of TORREYA partners. December 2011.