Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1RZVI)

• Drug Name: ICA-69673 Drug Info
• Synonyms: ICA-069673; Ion channel modulators (epilepsy), ICAgen; Ion channel modulators, ICAgen/ArQule

Indication

Disease Entry	ICD 11	Status	REF
Pain	MG30-MG3Z	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 10149311
  CAS Number: CAS 582323-16-8
  TTD Drug ID: DM1RZVI

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated potassium channel Kv7.3 (KCNQ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[3]
Linopirdine	DM0ZOGX	Cognitive impairment	6D71	Phase 3	[4]
ICA-105665	DMP925B	Epilepsy	8A60-8A68	Phase 2	[5]
XEN1101	DMJVL57	Epilepsy	8A60-8A68	Phase 1	[6]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[7]
PD-32577	DMBA15J	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Voltage-gated potassium channel Kv7.2 (KCNQ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[9]
PIP2	DMOZV7N	Discovery agent	N.A.	Investigative	[10]
PD-32577	DMBA15J	Discovery agent	N.A.	Investigative	[8]
zinc pyrithione	DMF0CRA	Discovery agent	N.A.	Investigative	[11]
XE991	DMLH1PK	Discovery agent	N.A.	Investigative	[12]
(S)-N-[1-(3-morpholin-4-yl-phenyl)-ethyl]-3-phenyl-acrylamide	DMGFOQJ	Discovery agent	N.A.	Investigative	[13]
QO-58	DMYXPF8	Discovery agent	N.A.	Investigative	[14]
ICA-27243	DMO0N3Q	Discovery agent	N.A.	Investigative	[15]
ztz240	DM60N3C	Discovery agent	N.A.	Investigative	[16]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv7.2 (KCNQ2)	TTPXI3S	KCNQ2_HUMAN	Modulator	[2]
Voltage-gated potassium channel Kv7.3 (KCNQ3)	TTIVDM3	KCNQ3_HUMAN	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011004)
• [2] Voltage-gated Potassium Channels as Therapeutic Drug Targets
• [3] The urinary safety profile and secondary renal effects of retigabine (ezogabine): a first-in-class antiepileptic drug that targets KCNQ (K(v)7) potassium channels. Epilepsia. 2012 Apr;53(4):606-12.
• [4] The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci. 2010;114(3):332-40.
• [5] New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels. Curr Neurol Neurosci Rep. 2008 Jul;8(4):345-52.
• [6] Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
• [7] Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol. 2000 Feb;129(3):413-5.
• [8] Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers. Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52.
• [9] Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol. 2000 Sep;58(3):591-600.
• [10] Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2005 Oct 26;25(43):9825-35.
• [11] Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96.
• [12] KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3.
• [13] The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels. Neuropharmacology. 2006 Nov;51(6):1068-77.
• [14] Modulation of K(v)7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br J Pharmacol. 2013 Feb;168(4):1030-42.
• [15] The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42.
• [16] Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J Biol Chem. 2010 Sep 3;285(36):28322-32.