General Information of Drug (ID: DM6SFYH)

Drug Name
[14C]TEA
Synonyms
Tetraethylammonium; Tetrylammonium; TETRAETHYLAMMONIUM ION; Tetramon; tetraethylazanium; N,N,N-Triethylethanaminium; tetraethylamine; UNII-5AV7G7EIEE; Tetraetilammonio [Italian]; 66-40-0; 5AV7G7EIEE; BRN 1738225; CHEMBL9324; AMMONIUM, TETRAETHYL-; CHEBI:44296; C8H20N; Tetraetilammonio; [14C]-TEA; tetraethyl ammonium; AC1L1KAW; Lopac-T-2265; 77-98-5 (hydroxide); 71-91-0 (bromide); 56-34-8 (chloride); 68-05-3 (iodide); SCHEMBL16267; 4-04-00-00331 (Beilstein Handbook Reference); NEt4(+); GTPL4575; GTPL2343; Ethanaminium,; [14C]-TEA ; tetraethylammonium
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1], [2]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 130.25
Topological Polar Surface Area (xlogp) 1.7
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 0
Chemical Identifiers
Formula
C8H20N+
IUPAC Name
tetraethylazanium
Canonical SMILES
CC[N+](CC)(CC)CC
InChI
InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
InChIKey
CBXCPBUEXACCNR-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5413
ChEBI ID
CHEBI:44296
CAS Number
66-40-0
DrugBank ID
DB08837
TTD ID
D06PZZ
VARIDT ID
DR00106

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aquaporin-1 (AQP1) TTSF1KH AQP1_HUMAN Inhibitor [3]
Calcium-activated potassium channel KCa2.1 (KCNN1) TT9R6BE KCNN1_HUMAN Blocker (channel blocker) [4]
Calcium-activated potassium channel KCa2.2 (KCNN2) TT2T5M0 KCNN2_HUMAN Blocker (channel blocker) [4]
Calcium-activated potassium channel KCa2.3 (KCNN3) TT9JH25 KCNN3_HUMAN Blocker (channel blocker) [4]
Calcium-activated potassium channel KCa4.1 (KCNT1) TTGJFK1 KCNT1_HUMAN Blocker (channel blocker) [5]
Calcium-activated potassium channel KCa4.2 (KCNT2) TTLU5FO KCNT2_HUMAN Blocker (channel blocker) [6]
Calcium-activated potassium channel KCa5.1 (KCNU1) TTI9XK6 KCNU1_HUMAN Blocker (channel blocker) [7]
Charybdotoxin receptor beta-4 (BKbeta4) TT1AQ50 KCMB4_HUMAN Inhibitor [8]
Inward rectifier potassium channel Kir2.3 (KCNJ4) TTXF0ZW KCNJ4_HUMAN Blocker (channel blocker) [9]
Multidrug and toxin extrusion protein 2 (MATE2) TT7HXSL S47A2_HUMAN Modulator [10]
Solute carrier family 47 member 1 (SLC47A1) TTMHCGA S47A1_HUMAN Modulator [11]
Transient receptor potential cation channel V2 (TRPV2) TTBECWA TRPV2_HUMAN Blocker (channel blocker) [12]
Voltage-gated potassium channel Kv1.1 (KCNA1) TTS3DIK KCNA1_HUMAN Blocker (channel blocker) [13]
Voltage-gated potassium channel Kv1.2 (KCNA2) TTVFB0O KCNA2_HUMAN Blocker (channel blocker) [13]
Voltage-gated potassium channel Kv1.3 (KCNA3) TTY3UE6 KCNA3_HUMAN Blocker (channel blocker) [13]
Voltage-gated potassium channel Kv1.5 (KCNA5) TTW0CMT KCNA5_HUMAN Blocker (channel blocker) [13]
Voltage-gated potassium channel Kv1.6 (KCNA6) TTJ2W69 KCNA6_HUMAN Blocker (channel blocker) [14]
Voltage-gated potassium channel Kv1.7 (KCNA7) TTCVBT7 KCNA7_HUMAN Blocker (channel blocker) [15]
Voltage-gated potassium channel Kv1.8 (KCNA10) TTT4Y0X KCA10_HUMAN Blocker (channel blocker) [16]
Voltage-gated potassium channel Kv2.1 (KCNB1) TT5OEKU KCNB1_HUMAN Blocker (channel blocker) [17]
Voltage-gated potassium channel Kv2.2 (KCNB2) TT5PFNG KCNB2_HUMAN Blocker (channel blocker) [18]
Voltage-gated potassium channel Kv3.1 (KCNC1) TTVUWHQ KCNC1_HUMAN Blocker (channel blocker) [13]
Voltage-gated potassium channel Kv3.2 (KCNC2) TTGK3ZO KCNC2_HUMAN Blocker (channel blocker) [19]
Voltage-gated potassium channel Kv3.3 (KCNC3) TTALSY9 KCNC3_HUMAN Blocker (channel blocker) [20]
Voltage-gated potassium channel Kv3.4 (KCNC4) TTODZF1 KCNC4_HUMAN Blocker (channel blocker) [21]
Voltage-gated potassium channel Kv4.1 (KCND1) TT4DI0J KCND1_HUMAN Blocker (channel blocker) [22]
Voltage-gated potassium channel Kv7.2 (KCNQ2) TTPXI3S KCNQ2_HUMAN Blocker (channel blocker) [23]
Voltage-gated potassium channel Kv7.3 (KCNQ3) TTIVDM3 KCNQ3_HUMAN Blocker (channel blocker) [24]
Voltage-gated potassium channel Kv7.4 (KCNQ4) TT8HGRW KCNQ4_HUMAN Blocker (channel blocker) [25]
Voltage-gated potassium channel Kv7.5 (KCNQ5) TTWVL5Q KCNQ5_HUMAN Blocker (channel blocker) [26]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation/carnitine transporter 1 (SLC22A4) DT2EG60 S22A4_HUMAN Substrate [27]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [28]
Multidrug and toxin extrusion protein 2 (SLC47A2) DT3TX4H S47A2_HUMAN Substrate [29]
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [30]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [31]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Multidrug and toxin extrusion protein 1 (SLC47A1) DTP MATE1 7.26E-02 -7.73E-01 -1.16E+00
Organic cation transporter 1 (SLC22A1) DTP SLC22A1 5.44E-01 1.29E-01 3.80E-01
Organic cation transporter 2 (SLC22A2) DTP SLC22A2 4.95E-01 -1.32E-01 -3.77E-01
Multidrug and toxin extrusion protein 2 (SLC47A2) DTP MATE2 5.64E-01 -1.09E-01 -1.98E-01
Organic cation/carnitine transporter 1 (SLC22A4) DTP OCTN1 3.41E-01 -7.96E-02 -1.50E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

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