Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1YCQF)

Drug Name

dolichol phosphate Drug Info

Synonyms

Dolichol-P; dolichol-phosphate; dolichyl-phosphate; Dolychol phosphate; Dolichol-PO4; AC1NQWWQ; GTPL3214; [(6E)-3,7,11-trimethyldodeca-6,10-dienyl] dihydrogen phosphate; {[(6E)-3,7,11-trimethyldodeca-6,10-dien-1-yl]oxy}phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5280322
CAS Number: CAS 34457-14-2
TTD Drug ID: DM1YCQF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(RS)-5-diphosphomevalonate	DMCPEBF	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mevalonate kinase (MVK)	TT5DFHW	KIME_HUMAN	Inhibitor	[2]

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References

1	A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy. Am J Hum Genet. 2007 Mar;80(3):433-40.
2	Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res. 1997 Nov;38(11):2216-23.
3	Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6.