Details of the Drug

General Information of Drug (ID: DM1YCQF)

Drug Name

dolichol phosphate

Synonyms

Dolichol-P; dolichol-phosphate; dolichyl-phosphate; Dolychol phosphate; Dolichol-PO4; AC1NQWWQ; GTPL3214; [(6E)-3,7,11-trimethyldodeca-6,10-dienyl] dihydrogen phosphate; {[(6E)-3,7,11-trimethyldodeca-6,10-dien-1-yl]oxy}phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

304.36

Logarithm of the Partition Coefficient (xlogp)

4

Rotatable Bond Count (rotbonds)

10

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

4

Chemical Identifiers

Formula: C15H29O4P
IUPAC Name: [(6E)-3,7,11-trimethyldodeca-6,10-dienyl] dihydrogen phosphate
Canonical SMILES: CC(CC/C=C(\\C)/CCC=C(C)C)CCOP(=O)(O)O
InChI: InChI=1S/C15H29O4P/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-19-20(16,17)18/h7,9,15H,5-6,8,10-12H2,1-4H3,(H2,16,17,18)/b14-9+
InChIKey: DZHSRPJGCZHWOM-NTEUORMPSA-N

Cross-matching ID

PubChem CID: 5280322
CAS Number: 34457-14-2
TTD ID: D0P9IA

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mevalonate kinase (MVK)	TT5DFHW	KIME_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	A defect in dolichol phosphate biosynthesis causes a new inherited disorder with death in early infancy. Am J Hum Genet. 2007 Mar;80(3):433-40.
2	Post-translational regulation of mevalonate kinase by intermediates of the cholesterol and nonsterol isoprene biosynthetic pathways. J Lipid Res. 1997 Nov;38(11):2216-23.