Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM26AB4)

Drug Name

L-Iso-Aspartate Drug Info

Synonyms

L-Iso-Aspartate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosfomycin	DMVGPMX	Bacterial infection	1A00-1C4Z	Approved	[2]
Uridine-Diphosphate-N-Acetylglucosamine	DMEQSTP	Discovery agent	N.A.	Investigative	[3]
RWJ-3981	DMBVLCQ	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
RWJ-140998	DMP7SI9	Gram-positive bacterial infection	1B74-1G40	Investigative	[4]
Aminomethylcyclohexane	DMNX9FC	Discovery agent	N.A.	Investigative	[1]
EUPATORIOPICRIN	DM068CY	Discovery agent	N.A.	Investigative	[5]
CNICIN	DMEVM0J	Discovery agent	N.A.	Investigative	[5]
Cyclohexylammonium Ion	DMYQH2N	Discovery agent	N.A.	Investigative	[1]
CYNAROPICRIN	DMG0PHU	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial UDP-N-acetylglucosamine carboxyvinyltransferase (Bact murA)	TTICX3S	MURA_ECOLI	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product release. J Biol Chem. 2005 Feb 4;280(5):3757-63.
3	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
4	Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
5	Sesquiterpene lactones are potent and irreversible inhibitors of the antibacterial target enzyme MurA. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5605-9.